Abstract #3673

Histogram analysis in prediction of Isocitrate Dehydrogenase Genotype in Gliomas with MRI: The Gaussian versus non-Gaussian Diffusion Models

Gao Ankang¹, Gao Eryuan¹, Zhang Huiting², Wang Shaoyu², Yan Xu², Bai Jie¹, and Cheng Jingliang¹

¹Dept. of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²MR Scientific Marketing, Siemens Healthcare, Shanghai, China, Shanghai, China

The Isocitrate dehydrogenase (IDH) genotyping and epigenetic 1p/19q codeletion as two key molecular markers are included in the glioma WHO 2016 classification. Gaussian or non-Gaussian diffusion models were recently proposed to provide additional microstructure information. In present work, we applied four diffusion models in glioma grading and genotyping, including DTI, DKI, MAP-MRI and NODDI models, which could be acquired within a single scan.

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