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Abstract #3673

Histogram analysis in prediction of Isocitrate Dehydrogenase Genotype in Gliomas with MRI: The Gaussian versus non-Gaussian Diffusion Models

Gao Ankang1, Gao Eryuan1, Zhang Huiting2, Wang Shaoyu2, Yan Xu2, Bai Jie1, and Cheng Jingliang1
1Dept. of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2MR Scientific Marketing, Siemens Healthcare, Shanghai, China, Shanghai, China

The Isocitrate dehydrogenase (IDH) genotyping and epigenetic 1p/19q codeletion as two key molecular markers are included in the glioma WHO 2016 classification. Gaussian or non-Gaussian diffusion models were recently proposed to provide additional microstructure information. In present work, we applied four diffusion models in glioma grading and genotyping, including DTI, DKI, MAP-MRI and NODDI models, which could be acquired within a single scan.

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