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Abstract #3675

Beyond cellularity: Which microstructural features determine the mesoscopic mean diffusivity in meningiomas?

Jan Brabec1, Filip Szczepankiewicz2, Jaromír Šrámek3, Elisabet Englund4, Johan Bengzon5, Linda Knutsson1,6, Carl-Fredrik Westin7,8, Pia C Sundgren2,9, and Markus Nilsson2
1Medical Radiation Physics, Lund University, Lund, Sweden, 2Diagnostic Radiology, Lund University, Lund, Sweden, 3Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 4Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden, 5Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden, 6Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Harvard Medical School, Boston, MA, United States, 8Radiology, Brigham and Women’s Hospital, Boston, MA, United States, 9Lund University Bioimaging Center, Lund University, Lund, Sweden

Mean diffusivity (MD) in tumors is often too readily interpreted as cellularity. Here, we investigated which microstructural features explain the MD in meningioma tumors. We performed high-resolution MRI and histological imaging on excised mengioma tumor samples and coregistered MD to histology. We found that cellularity alone was a poor predictor of MD, and that the prediction improved markedly by considering also the microcyst density. A qualitative analysis also indicated that collagen fibers, stroma and psammoma bodies affect the MD.

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