Abstract #3708

CEST imaging with neural network fitting of the human brain at 3T

Zhichao Wang¹, Yu Zhao², Xu Yan³, Zhongshuai Zhang³, Caixia Fu³, Hui Tang⁴, and Jianqi Li¹

¹Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China, ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, ⁴Department of Radiology, Renji Hospital affiliated to Shanghai Jiao Tong University Medical College, Shanghai, China

Chemical exchange saturation transfer (CEST) imaging shows great potential in clinical application. Separating the nuclear Overhauser enhancement (NOE) and amide proton transfer (APT) effects properly is highly valuable for clinical application of CEST. In this study, the background Z-spectra including only the magnetization transfer and direct saturation effects was fitted by using neural network, then CEST and NOE maps were obtained simultaneously. The reproducibility and feasibility of new method were demonstrated in four healthy volunteers and two patients with ischemic stroke.

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