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Abstract #3725

Temporal correlation of functional connectivity and Choline in the monkey brain following ischemic stroke

Chun-Xia Li1, Frank Tong2, Doty Kempf1, Leonard Howell1, and Xiaodong Zhang1
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Department of Radiology, Emory University, Atlanta, GA, United States

Previous studies have suggested cerebral Choline (Cho) is a sensitive marker of acute stroke and could protect the tissue from ischemic injury. Also the relative connectivity (RelCon) could be a robust index to reveal the functional connectivity changes using resting state fMRI (rs-fMRI). The results indicated progressively increased RelCon in secondary somatosensory cortex (RelCon-S2) and a significant positive correlation between RelCon-S2 and relative cerebral Choline level (RelCho) from hyper-acute phase to 96 hours post stroke. The RelCon and RelCho combined detection might be an optimized and promising approach in management and prediction of stroke recovery.

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