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Abstract #3755

Investigation of TES Simulation Sensitivity to Skull Simplification using a Multimodal MR-Based Detailed Head Model

William Wartman1, Kyoko Fujimoto2, Mohammad Daneshzand3, Sergey Makarov1,3, and Aapo Nummenmaa3
1Electrical and Computer Engineering Department, Worcester Polytechnic Institute, Worcester, MA, United States, 2Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, United States, 3Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

One of the most detailed multimodal human head models currently available (MIDA, 0.5 mm isotropic res., 100+ compartments) is accurately analyzed numerically to investigate the effects of the fine structure of the skull on transcranial electrical stimulation (TES). A simplified case, where the diploƫ and dura are treated as cortical bone, is compared against the full-model case. For each electrode in a 10-10 configuration, coefficients are computed independently to scale the cortical fields from the simplified case to match the cortical fields from the realistic case, investigating the topological field differences in the process.

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