Meeting Banner
Abstract #3810

Simulating the Effects of Diffusion on Hyperpolarized [1-13C]-Pyruvate Signal Evolution

Reshmi J. S. Patel1, Collin J. Harlan1, and James A. Bankson1,2
1Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, United States

Hyperpolarized [1-13C]-pyruvate MRI is an emerging imaging method that offers unprecedented spatiotemporal resolution for monitoring tumor metabolism in vivo. To establish a robust imaging biomarker, we must characterize phenomena that may modulate the apparent conversion rate of pyruvate into lactate (kpl). We sought to investigate the potential effect of diffusion on pyruvate-to-lactate conversion. HP signal evolution, as calculated by finite-difference time domain simulation of a 2D tissue model, was fit to a two-compartment pharmacokinetic model. Results indicate for low intracellular kpl, diffusion has a minimal impact, but pyruvate diffusion can reduce the apparent rate of conversion at high intracellular kpl.

This abstract and the presentation materials are available to members only; a login is required.

Join Here