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Abstract #3832

Cardiac MRI detects a reduced volume and anti-inflammatory fatty acid composition of epicardial adipose tissue in eplerenone-treated obese mice

Soham A Shah1, Brent French1, Matthew Wolf1, and Fred Epstein1
1University of Virginia, Charlottesville, VA, United States

Epicardial adipose tissue (EAT) volume and fatty acid composition (FAC) have significant roles in EAT-mediated coronary vascular inflammation. Using MRI of EAT volume and FAC, we tested the hypothesis that eplerenone reduces EAT volume and alters its FAC in a mouse model of obesity. We show that eplerenone significantly reduces EAT volume after 30 weeks on a high-fat high-sucrose diet compared to untreated mice. In addition, the EAT FAC is shifted from saturated fatty acid dominant in untreated mice to poly-unsaturated fatty acid dominant in eplerenone-treated mice. The results suggest that eplerenone has an anti-inflammatory role in obesity-related EAT.

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