This study investigated the in vivo effects on acetylcarnitine levels in the heart and the liver after an injection of L-carnitine. Carnitine acts as a buffer of acetyl-CoA units in the mitochondria, as well as facilitating transport of fatty acids. We show that an injection of L-carnitine can alter cardiac lipid levels in the in vivo healthy human. However, even though L-carnitine injection shows high cardiac variability in acetylcarnitine levels, hepatic variability of acetylcarnitine levels were reduced. Further studies are needed to confirm the dose and time-frame of a response in acetylcarnitine levels after L-carnitine injections.
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