Meeting Banner
Abstract #3834

Cardiac and Hepatic Metabolism Modulation using L-carnitine injection: 1H Magnetic Resonance Spectroscopy Study

Dragana Savic1, Ferenc E. Mózes1, Matthew K. Burrage1, Leanne Hodson1, Stefan Neubauer1, Michael Pavlides1, Damian J. Tyler1, and Ladislav Valkovic1
1University of Oxford, Oxford, United Kingdom

This study investigated the in vivo effects on acetylcarnitine levels in the heart and the liver after an injection of L-carnitine. Carnitine acts as a buffer of acetyl-CoA units in the mitochondria, as well as facilitating transport of fatty acids. We show that an injection of L-carnitine can alter cardiac lipid levels in the in vivo healthy human. However, even though L-carnitine injection shows high cardiac variability in acetylcarnitine levels, hepatic variability of acetylcarnitine levels were reduced. Further studies are needed to confirm the dose and time-frame of a response in acetylcarnitine levels after L-carnitine injections.

This abstract and the presentation materials are available to members only; a login is required.

Join Here