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Abstract #3841

Noninvasive in vivo assessment of liver fat on a mouse model of diet-induced fatty liver disease using 3-Tesla MRI.

Orlando Aristizabal1, Lakshmi Arivazhagan1, AnnMarie Schmidt1, Edward A Fisher 1, Kathryn Moore1, and Youssef Zaim Wadghiri1
1NYU Grossman School of Medicine, New York, NY, United States

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in the Western The development of preclinical mouse models is essential in the development of virtual biopsy protocols to assess the essential features of NAFLD. In this report we have examined the feasibility of visualizing and mapping the fat fraction in mice under 2 high fat diets and one control diet using a preclinical 3-Tesla MRI with a RARE-Dixon sequence. We show that at 3T fat and water can be separated and percentage maps show a 23% and 39% increase in liver fat over the control mouse.

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