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Abstract #3848

Optimal experimental design for quantitative water, fat and silicone separation using a variable projection method with 4 or 6 echoes at 3T

Jonathan K. Stelter1, Christof Boehm1, Stefan Ruschke1, Maximilian N. Diefenbach1,2, Mingming Wu1, Kilian Weiss3, Tabea Borde1, Stephan Metz1, Marcus R. Makowski1, and Dimitrios C. Karampinos1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany, 3Philips Healthcare, Hamburg, Germany

Patients with silicone breast implants undergoing MR mammography are examined with a water- and fat-suppressed sequence to verify the implant’s integrity. In parallel, chemical shift encoding-based water–fat separation has been recently used for quantifying breast water-fat composition to assess breast density and for extracting magnetic susceptibility maps to detect breast calcifications. In this work, a water–fat–silicone separation method is developed for a joint estimation of all three components and applied with NSA-optimized echo times to simulated single-voxel data, scanner phantom and in vivo data showing robust species separation and fat fraction mapping.

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