Abstract #3861

Temperature-Corrected Proton Density Fat Fraction Estimation using Magnitude, Complex, and Hybrid Chemical Shift-Encoded MRI in Phantoms

Ruvini Navaratna^1,2, Ruiyang Zhao^1,2, Timothy J Colgan², Houchun Harry Hu³, Mark Bydder⁴, Takeshi Yokoo⁵, Mustafa R Bashir^6,7,8, Michael S Middleton⁹, Suraj D Serai¹⁰, Dariya Malyarenko¹¹, Thomas Chenevert¹¹, Mark Smith³, Walter Henderson⁹, Gavin Hamilton⁹, Yunhong Shu¹², Claude B Sirlin⁹, Jean Tkach¹³, Andrew T Trout^13,14, Jean H Brittain¹⁵, Diego Hernando^1,2, and Scott B Reeder^1,2,16,17,18

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, University of Wisconsin - Madison, Madison, WI, United States, ³Radiology, Nationwide Children's Hospital, Columbus, OH, United States, ⁴Radiological Sciences, University of California - Los Angeles, Los Angeles, CA, United States, ⁵Radiology, University of Texas - Southwestern Medical Center, Dallas, TX, United States, ⁶Radiology, Duke University Medical Center, Durham, NC, United States, ⁷Division of Hepatology, Duke University Medical Center, Durham, NC, United States, ⁸Center for Advanced Magnetic Resonance Development, Duke University Medical Center, Durham, NC, United States, ⁹Radiology, University of California - San Diego, San Diego, CA, United States, ¹⁰Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ¹¹Radiology, University of Michigan, Ann Arbor, MI, United States, ¹²Radiology, Mayo Clinic, Rochester, MN, United States, ¹³Radiology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, United States, ¹⁴Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States, ¹⁵Calimetrix, LLC, Madison, WI, United States, ¹⁶Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ¹⁷Medicine, University of Wisconsin - Madison, Madison, WI, United States, ¹⁸Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

Chemical shift-encoded (CSE) MRI is a well-established technique to quantify proton density fat-fraction (PDFF) as a quantitative imaging biomarker of hepatic steatosis. However, temperature is known to affect the accuracy and precision of PDFF quantification in phantoms. Previous work has demonstrated the benefit of temperature-correction using magnitude-based CSE-MRI PDFF estimation. However, the effect of temperature correction on complex- and hybrid-based CSE-MRI PDFF estimation is unknown. In this study, we aim to compare the effects of PDFF temperature-correction for magnitude-based, complex-based, and hybrid-based CSE-MRI using simulations, temperature-controlled phantom experiments, and a multi-center phantom study.

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