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Abstract #3912

Vascular input function measurement in brain tumor DCE-MRI: a comparison of arterial and venous sinus based approaches

Xiaoping Zhu1, Daniel Lewis2, Ka-Loh Li1, Sha Zhao3, Timothy Cootes1, Andrew King2, David Coope2, and Alan Jackson3
1DIIDS, University of Manchester, Manchester, United Kingdom, 2Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom, 3University of Manchester, Manchester, United Kingdom

Accurate derivation of a vascular input function (VIF) is essential for pharmacokinetic modeling of brain DCE-MRI data. In this patient study we compared VIFs extracted from either the internal carotid artery (ICA) and its branches or the superior sagittal sinus (SSS). We demonstrate that plasma gadolinium based contrast-agent (GBCA) concentration-time curves during the 1st-pass of the bolus are equivalent in shape in both the ICA and SSS; and that compared to large intracranial arteries the SSS is able to provide a superior global VIF, with lower noise, higher peak-amplitude and demonstrably greater sensitivity to inter-individual changes in plasma GBCA concentration.

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