This prospective, single-arm, cohort patients study with a newly diagnosed head&neck cancer aims to demonstrate the feasibility of multiparametric MRI to reveal tumor hypoxia and treatment failure. Although tumor hypoxia is a critical physiologic feature related to treatment resistance and poor outcomes, effective imaging technology to detect the area of hypoxia in an individual patient is lacking. Incorporating multiparametric maps into cross-sectional imaging is critically essential for translating imaging information to radiation dose paining. We generated the composite color map incorporating oxygen-enhanced BOLD, ADC, and FDG-PET and correlated it with CRT response at 3 months, as a proof of concept.
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