DWI helps reveal many neurological disorders. However, its application in the optic nerve and pituitary gland is hindered by strong distortion artifacts associated with ssEPI, the method of choice for clinical DWI. Recently, IRIS (an msEPI sequence) and SPLICE-PROPELLER (a distortion-free technique) have become available in the clinic. In this work, we develop and optimize DWI protocols for imaging the optic nerve and pituitary gland. Volunteer studies and patient scans demonstrate immunity to geometric distortions, and good overall image quality with clinically friendly scan times.