Retrospective analysis of patients with brain MRI examination and confirmed by pathology, respectively in three groups of MR ADC axial images, using Mazda software to delineate the region of interest at each level of the tumor, and carry out gray-scale global histogram analysis, and statistical analysis of the three groups of histogram parameter characteristics.The nine parameters, mean, variance, kurtosis, skewness, perc. 01%, perc. 10%, perc. 50%, perc. 90% and perc. 99% were obtained by gray histogram analysis (P < 0.05).