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Abstract #3945

Diagnostic Consensus in the Interpretation of Ultra-High-Field MRS in Glioma Patients 

Uzay E Emir1,2, Jannie Wijnen3, Olaf E Ansorge4, Evita Wiegers3, Anja van der Kolk5, Alexander Lin6, and Clark Chen7
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, 4University of Oxford, Oxford, United Kingdom, 5Antoni van Leeuwenhoek Hospital, Netherlands Cancer Center, Amsterdam, Netherlands, 6Brigham and Women’s Hospital / Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, United States, 7Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States

We have recently initiated a 7T MRS glioma consortium, intending to bring together experts in the field to discuss pitfalls, promises, and potential research avenues of MRS in gliomas. During the "GlioMaRS-NET Workshop" in 2020, we tested the efficacy of UHF MRS for predicting the molecular characteristics by visual inspection by conducting a survey with a set of previously acquired UHF spectra from glioma patients. There was a high concordance in diagnostic interpretation of spectra for the identification of IDH-mutant gliomas versus IDH-wildtype gliomas.

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