Abstract #3974

Reproducibility of R2* and quantitative susceptibility mapping in deep grey matter at 3T: Cross-vendor non-harmonized protocol study

Nashwan Naji¹, M. Louis Lauzon^2,3, Peter Seres¹, Emily Stolz¹, Richard Frayne^2,3, Catherine Lebel⁴, Christian Beaulieu¹, and Alan H. Wilman¹

¹Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ²Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada, ⁴Department of Radiology, Alberta Children’s Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

R2* and QSM provide noninvasive ways to measure iron concentration in human brain. Performing multi-center studies help exploring wider demographical and pathological conditions. However, data pooled from multiple sites typically contain local acquisition sequence variations. In this study, the reproducibility of R2* and QSM at 3T are evaluated in 21 healthy adults (“traveling phantoms”) scanned 2x per site using independently site-optimized sequences from three sites and two scanner vendors. Mean R2* and susceptibility measurements in four deep grey matter structures were found to be highly correlated (r² ≥ 0.98) and reproducible with SD of 1.2 s^-1 and 4.1 ppb, respectively.

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