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Abstract #3974

Reproducibility of R2* and quantitative susceptibility mapping in deep grey matter at 3T: Cross-vendor non-harmonized protocol study

Nashwan Naji1, M. Louis Lauzon2,3, Peter Seres1, Emily Stolz1, Richard Frayne2,3, Catherine Lebel4, Christian Beaulieu1, and Alan H. Wilman1
1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada, 4Department of Radiology, Alberta Children’s Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

R2* and QSM provide noninvasive ways to measure iron concentration in human brain. Performing multi-center studies help exploring wider demographical and pathological conditions. However, data pooled from multiple sites typically contain local acquisition sequence variations. In this study, the reproducibility of R2* and QSM at 3T are evaluated in 21 healthy adults (“traveling phantoms”) scanned 2x per site using independently site-optimized sequences from three sites and two scanner vendors. Mean R2* and susceptibility measurements in four deep grey matter structures were found to be highly correlated (r2 ≥ 0.98) and reproducible with SD of 1.2 s-1 and 4.1 ppb, respectively.

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