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Abstract #3985

Quantitative susceptibility mapping MRI of brain iron and PET of β-amyloid predict cognitive decline during aging

Lin Chen1,2, Anja Soldan3, Kenichi Oishi1, Andreia Faria1, Marilyn Albert3, Peter van Zijl1,2, and Xu Li1,2
1Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

We investigated associations of brain volume, iron levels as measured by QSM-MRI, and β-amyloid plaque load as measured by 11C-PiB PET imaging on prospective cognitive trajectories, measured using a global and domain-specific cognitive composite scores (e.g., episodic memory, executive function, visuospatial processing and language) in cognitively normal older adults with maximum follow-up of 5 years. Greater volume of multiple cortical and subcortical brain regions was strongly associated with the rate of cognitive decline. Associations between brain iron and β-amyloid and longitudinal cognitive decline were weaker, with brain iron in the basal ganglia and entorhinal cortex predicting global decline.

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