Accurate needle placement is crucial for MRI-guided targeted prostate biopsy. However, needle placement accuracy is often affected by the deviation of the needle caused by the anatomical structures on the needle path. To avoid anatomical structures that are likely to cause significant needle deviation, we developed a 4-degree-of-freedom (DoF) needle-guide manipulator system named “Smart Template”. The Smart Template allows physicians to insert a needle accurately to the target while monitoring the needle through interactive real-time MRI. We performed a preliminary evaluation of the device to test the feasibility of needle placement using Smart Template.