A growing body of literature demonstrates the value of MRI-based volumetric measures in diagnosing and treating neurodegenerative disorders. However, clinicians cannot offer biomarker screening for at-risk patients due to MRI systems’ high cost and limited access. Low-field MRI scanners offer a potential method for collecting low-cost images that could be analyzed for longitudinal biomarker changes or used in population-level studies. Here we examine the reliability of volumetric measurements made on a low-field MRI system. We compare the variability of 6 tissue volumes collected over 40 scans for 3T and 64mT systems, as well as the overlap between volume segmentations.