The purpose of this study is to investigate whether individuals with diabetes mellitus and incompressible arteries will have lower skeletal muscle microcirculation during a moderate isometric exercise. Healthy volunteers, diabetes with normal artery, and diabetes with incompressible arteries underwent MR angiography and calcification imaging, and skeletal muscle microcirculation imaging at rest and during an isometric contraction exercise. Significantly lower perfusion reserve and its association with higher ABI were observed in diabetes with incompressible arteries. Despite lack of apparent arterial stenosis, calcification can be readily visualized in 2 patients.
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