Abstract #4069

Significantly reduced collagen and increased water in tibia of patients with osteopenia and osteoporosis detected with ultrashort echo time MRI

Saeed Jerban¹, Yajun Ma¹, Zhao Wei¹, Meghan Shen¹, Amir Masoud Afsahi¹, Zubiad Ibrahim¹, Alecio Lombardi^1,2, Douglas G Chang³, Eric Y Chang^1,2, and Jiang Du¹

¹Radiology, University of California, San Digeo, La Jolla, CA, United States, ²Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, ³Orthopaedic Surgery, University of California, San Digeo, La Jolla, CA, United States

Assessment of water and collagen content in bone is missing from DEXA evaluation, in standard osteoporosis diagnosis. Bone signals in ultrashort echo time MRI (UTE-MRI) and inversion recovery UTE-MRI against a known external reference signal were used to measure total, bound, and pore water proton densities. Macromolecular proton density was estimated by multiplying total water proton density with macromolecular fraction derived from UTE magnetization transfer (UTE-MT) modeling. The UTE-evaluated MRI measures demonstrated significantly reduced collagen and increased water content in the tibia of patients with osteoporosis and osteopenia compared with healthy subjects. Hip T-scores showed significant correlation with UTE-MRI measures.

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