Meeting Banner
Abstract #4069

Significantly reduced collagen and increased water in tibia of patients with osteopenia and osteoporosis detected with ultrashort echo time MRI

Saeed Jerban1, Yajun Ma1, Zhao Wei1, Meghan Shen1, Amir Masoud Afsahi1, Zubiad Ibrahim1, Alecio Lombardi1,2, Douglas G Chang3, Eric Y Chang1,2, and Jiang Du1
1Radiology, University of California, San Digeo, La Jolla, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, 3Orthopaedic Surgery, University of California, San Digeo, La Jolla, CA, United States

Assessment of water and collagen content in bone is missing from DEXA evaluation, in standard osteoporosis diagnosis. Bone signals in ultrashort echo time MRI (UTE-MRI) and inversion recovery UTE-MRI against a known external reference signal were used to measure total, bound, and pore water proton densities. Macromolecular proton density was estimated by multiplying total water proton density with macromolecular fraction derived from UTE magnetization transfer (UTE-MT) modeling. The UTE-evaluated MRI measures demonstrated significantly reduced collagen and increased water content in the tibia of patients with osteoporosis and osteopenia compared with healthy subjects. Hip T-scores showed significant correlation with UTE-MRI measures.

This abstract and the presentation materials are available to members only; a login is required.

Join Here