Abstract #4080

A Comparison of Synovitis Severity in the Knee Assessed Using Contrast-Enhanced MRI and FDG-PET

Jacob Thoenen¹, James W. MacKay^2,3, Kathryn J. Stevens¹, Tom D. Turmezei⁴, Akshay Chaudhari¹, Lauren E. Watkins¹, Brian A. Hargreaves¹, Garry E. Gold¹, and Feliks Kogan¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ³Norwich Medical School, University of East Anglia, Norwich, United Kingdom, ⁴Department of Radiology, Norfolk and Norwich University Hospital, Norwich, United Kingdom

T1-weighted contrast-enhanced MRI (CE-MRI) is used to evaluate synovitis, but fluctuations in severity of synovial inflammation may be slow to manifest as volumetric changes seen on CE-MRI. We compared metabolic activity using FDG-PET to CE-MRI synovitis gradings, MOAKS effusion- and Hoffa-synovitis gradings, and the transfer constant K^trans in the overall synovial region and four subregions. Moderate to very strong correlation was seen between maximum FDG uptake (SUV_max) and corresponding synovitis grades, MOAKS effusion synovitis, and corresponding regional median K^trans both within the entire synovium and in four synovial subregions, with the exception of median K^trans at one subregion.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.