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Abstract #4099

­­­­Physically Implausible Diffusion Signals (PIDS) as a Quality Assessment Metric in Prostate DWI

Teodora Szasz1, Milica Medved2, Aritrick Chatterjee2, Ajit Devaraj3, Ambereen Yousuf2, Xiaobing Fan2, Gregory Karczmar2, Aytekin Oto2, and Grace Lee2
1Research Computing Center, The University of Chicago, Chicago, IL, United States, 2Department of Radiology, The University of Chicago, Chicago, IL, United States, 3Philips Research North America, Chicago, IL, United States

Diffusion weighted imaging (DWI) is important for prostate cancer diagnosis but is highly sensitive to artifacts. We developed a method for automatically and quantitatively measuring physically implausible DWI signals (PIDS) that could contribute to diagnostic errors. The level of PIDS is significant and similar in all prostate zones, for scans both with and without an endorectal coil, and is strongly correlated with motion. For scans without the endorectal coil, PIDS is correlated with noise level. In regions with a high percentage of PIDS, PIRADS II criteria may not be optimal, and algorithms that emphasize T2 and DCE-MRI may be preferable.

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