Identifying repeatability of radiomic features in T2-Weighted prostate MRI is important to develop consistent imaging biomarkers and evaluate prostate cancer. This study aims to investigate the impact of pre-processing configurations on radiomic features repeatability in two short-term measurements. Repeatability was analyzed through pre-processing combinations of quantization, bin number, normalization, and filtering, and PyRadiomics feature extraction tool. The results show that repeatability of texture features varies depending on anatomical zones and lesions, pre-processing, and feature itself. Four texture features provide good repeatability independently of pre-processing configuration. Moreover, different feature groups have the highest repeatability in whole prostate, prostate zones and lesions.
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