Abstract #4132

Cortical microinfarcts on 7T MRI correlate with medial temporal lobe thinning in healthy aging

Shokufeh Sadaghiani¹, M. Dylan Tisdall², Sandhitsu R. Das¹, David A. Wolk¹, and John A. Detre¹

¹Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, ²Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

We investigated the correlation of CMIs with MTL subregional cortical thickness in 21 healthy elderly subjects. We also showed that only 26% of total CMIs visible on 7T MRI scans are also visible on 3T scans suggesting a better visualization of CMIs by 7T MRI compared to 3T MRI. Our findings support an interaction between cerebrovascular and neurodegenerative mechanisms in healthy aging.

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