Abstract #4134

Neuropathologic correlates of cerebral microbleeds in community-based older adults

Grant Nikseresht¹, Ashish A. Tamhane², Nazanin Makkinejad³, Carles Javierre-Petit³, Gady Agam¹, David A. Bennett², Julie A. Schneider², and Konstantinos Arfanakis^2,3

¹Department of Computer Science, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, ³Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States

Cerebral microbleeds (CMBs) are common in older adults and have been linked to hypertension, increased risk of stroke, and cognitive decline. There is also evidence of an association between CMBs and cerebral amyloid angiopathy (CAA) in studies involving clinical populations and patients with intracerebral hemorrhage. However, it remains unclear what the neuropathologic correlates of CMBs are in community-based older adults. The aim of this study was to determine the neuropathologic correlates of CMBs in community-based older adults, and also to investigate the relationship between neuropathologies and the location of CMBs in the brain.

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