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Abstract #4142

Can different etiologies provide converging evidence regarding the neural correlates of cognitive performance? Tumor versus stroke

Eva van Grinsven1, Anouk Smits1, Emma van Kessel1, Mathijs Raemaekers1, Edward de Haan2, Irene Huenges Wajer1,3, Veerle Ruijters1, Marielle Philippens4, Joost Verhoeff4, Pierre Robe1, Tom Snijders1, and Martine van Zandvoort1,3
1Department of Neurology & Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, Netherlands, 2Department of Psychology, University of Amsterdam, Amsterdam, Netherlands, 3Department of Experimental Psychology and Helmholtz Institute, Utrecht University, Utrecht, Netherlands, 4Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands

While lesion-symptom mapping can inform on which brain regions are crucial for a given behavior, it is still unclear whether different lesion etiologies show comparable structure-function relationships. In this study, support-vector regression lesion-symptom maps were compared between a glioma and stroke population. As expected, pathology distinct coverage patterns in the brain were found and there were more and larger significant voxel clusters in the tumor group. Our preliminary conclusion is that despite some differences in lesion-symptom associations in comparing a tumor and stroke population, these two populations can provide complementary information regarding involvement of brain regions for given cognitive tasks.

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