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Abstract #4146

Quantification of hemodynamics of cerebral arteriovenous malformations after stereotactic radiosurgery using 4D Flow MRI

Shanmukha Srinivas1, Tara Retson1, Aaron Simon2, Marc Alley3, Shreyas Vasanawala3, Jona Hattangadi-Gluth2, Albert Hsiao1, and Nikdokht Farid1
1Department of Radiology, University of California San Diego, San Diego, CA, United States, 2Department of Radiation Medicine and Applied Sciences, University of California San Diego, San Diego, CA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States

This study evaluated the use of 4D flow MRI to assess hemodynamic changes to cerebral arteriovenous malformations after stereotactic radiosurgery (SRS). As a comparison, structural changes of AVMs were measured on T2W single shot fast spin echo (SSFSE) and time-of-flight (TOF) angiography. Hemodynamic changes, including reduction in feeding arterial flow and draining venous flow, preceded structural changes including arterial circumference and nidus volume for large arteriovenous malformations. This study demonstrated the potential utility of 4D flow MRI as a robust tool to supplement existing imaging techniques and measure early treatment response after stereotactic radiosurgery (SRS).

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