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Abstract #4148

Measuring pulse wave velocity in the cerebral arterial tree using 4D flow MRI 

Cecilia Björnfot1, Anders Garpebring1, Sara Qvarlander1, Jan Malm2, Anders Eklund1, and Anders Wåhlin1,3
1Department of Radiation Sciences, Umeå University, Umeå, Sweden, 2Department of Clinical Sciences, Umeå University, Umeå, Sweden, 3Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden

Age-related arterial wall hardening could be detrimental to brain function via several pathways. A consequence of vessel wall hardening is the increased velocity at which the cardiac-induced pulse wave travels. Previously, pulse wave velocity in the aorta and extracranial arteries have been linked to brain pathology. However, there's a lack of “target-organ” measurements. Here we present a 4D flow MRI method to estimate pulse wave velocity in the cerebral arterial tree. The method is shown to be stable in an internal consistency test, and of sufficient sensitivity to robustly detect age-related increases in intracranial pulse wave velocity.

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