Abstract #4163

Investigation into the Cerebrovascular Effects of Gender Affirming Therapy in Transgender Men using TOF-MRA and pCASL

Samantha Cote¹, Reihaneh Forouhandehpour¹, Etienne Croteau¹, Diane Rottembourg², Jean-Francois Lepage², and Kevin Whittingstall³

¹Département de médecine nucléaire et radiobiologie, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Département de pédiatrie, Université de Sherbrooke, Sherbrooke, QC, Canada, ³Département de radiologie diagnostique, Université de Sherbrooke, Sherbrooke, QC, Canada

We investigated if gender affirming hormonal therapy (GAHT) in young transgender men receiving testosterone (T) impacts cerebrovascular function and structure using pseudo-continuous arterial spin labelling (pCASL) and time of flight magnetic resonance angiography (TOF). We observed decreases in CBF and arterial vessel diameter. These results suggest an association between increased serum T and decreases in CBF which may be related to changes in cerebrovascular morphology.

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