Abstract #4165

High-resolution, low-SAR 3D T2 relaxometry with COMBINE

Peter J Lally¹, Matthew Grech-Sollars^2,3, Joely Smith^3,4, Ben Statton⁵, Paul M Matthews^1,6, Karla L Miller⁷, and Neal K Bangerter⁴

¹Department of Brain Sciences, Imperial College London, London, United Kingdom, ²Department of Surgery and Cancer, Imperial College London, London, United Kingdom, ³Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, ⁴Department of Bioengineering, Imperial College London, London, United Kingdom, ⁵MRC London Institute of Medical Sciences, London, United Kingdom, ⁶UK Dementia Research Institute Centre at Imperial College, London, United Kingdom, ⁷Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Here we describe a super-resolution 3D T₂ relaxometry approach using an unbalanced SSFP acquisition with very low flip angle RF pulses (α ≤ 1°). We then apply this to obtain 1mm isotropic T₂ maps in a reference phantom, and compare this to both the reference values and a 2D multi-echo spin echo approach. The proposed approach provides new options for high-resolution, low-SAR T₂ relaxometry experiments in a range of tissues.

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