Single-shot echoplanar imaging (EPI) sequence is a commonly used readout scheme for functional and diffusion magnetic resonance imaging (fMRI and dMRI). It features fast alternating gradient that generate loud acoustic noise, often causing discomfort for patients and even pose risk for sensitive populations. In this study, we used genetic algorithm to optimize both sound pressure level and spectral entropy for single-shot EPI sequence by varying the duration of each readout unit with a sinusoidal waveform, changing the timbre significantly with increased entropy and reduced loudness. The sequence was implemented on a 3.0T pediatric uMR Alpha system.
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