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Abstract #4201

Optimized DANTE preparation for intracranial DANTE-SPACE vessel wall imaging at 7T

Matthijs de Buck 1, Aaron Hess2, and Peter Jezzard1
1Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

DANTE-SPACE can be used for visualizing intracranial vessel walls at 7T by simultaneously suppressing signal from the luminal blood and external CSF. However, vessel wall delineation is limited by the achieved contrast and resolution, and further improvement of the sequence is constrained by SAR. Here, an optimized protocol for the number of DANTE-pulses and the flip angle of each DANTE-pulse is proposed based on an EPG-based simulation framework. In-vivo data acquired using this DANTE preparation show an improved CNR and signal ratio between the vessel wall and both blood and CSF, while reducing the SAR compared to previous DANTE preparations.

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