No medical therapies have been shown to halt or slow the progression of post-traumatic osteoarthritis (PTOA), which develops after acute/repetitive injury to a joint. Improvements in non-invasive methods to assess PTOA will help diagnose stages for early clinical interventions. Rabbits offer a translationally relevant animal model where anterior cruciate ligament (ACL) injury allows for monitoring PTOA progression, determining a treatment window for early invention. In this work, we leveraged the high signal-to-noise ratio (SNR) of magnetic resonance imaging at 7T to develop a quantitative, non-invasive, 3D-ultrahigh-resolution dGEMRIC MRI exam for femoral-tibial observations and T1 quantification of matrix changes in rabbits.
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