Abstract #4241

Assessment of Synovitis in Osteoarthritis Using Non-Contrast Quantitative DESS

Jacob Thoenen¹, James W. MacKay^2,3, Kathryn J. Stevens¹, Tom D. Turmezei⁴, Akshay Chaudhari¹, Lauren E. Watkins¹, Emily J. McWalter⁵, Brian A. Hargreaves¹, Garry E. Gold¹, and Feliks Kogan¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ³Norwich Medical School, University of East Anglia, Norwich, United Kingdom, ⁴Department of Radiology, Norfolk and Norwich University Hospital, Norwich, United Kingdom, ⁵Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada

Quantitative double-echo in steady-state (qDESS) MRI has been proposed as an alternative to T1-weighted contrast enhanced MRI (CE-MRI) for evaluation of synovitis. In comparison with CE-MRI by, four radiologists, qDESS with a low diffusion gradient (qDESS_Low), and qDESS with a high diffusion gradient (qDESS_High) both showed good agreement to CE-MRI for the overall and regional impressions of synovitis, as well as good inter- and intra- rater agreement. Further, radiologists rated qDESS_Low and qDESS_High with moderate-to-high and moderate diagnostic confidence, respectively. This work shows the potential of the qDESS sequence as a non-contrast imaging technique for evaluation of synovitis.

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