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Abstract #4241

Assessment of Synovitis in Osteoarthritis Using Non-Contrast Quantitative DESS

Jacob Thoenen1, James W. MacKay2,3, Kathryn J. Stevens1, Tom D. Turmezei4, Akshay Chaudhari1, Lauren E. Watkins1, Emily J. McWalter5, Brian A. Hargreaves1, Garry E. Gold1, and Feliks Kogan1
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 3Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 4Department of Radiology, Norfolk and Norwich University Hospital, Norwich, United Kingdom, 5Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada

Quantitative double-echo in steady-state (qDESS) MRI has been proposed as an alternative to T1-weighted contrast enhanced MRI (CE-MRI) for evaluation of synovitis. In comparison with CE-MRI by, four radiologists, qDESS with a low diffusion gradient (qDESSLow), and qDESS with a high diffusion gradient (qDESSHigh) both showed good agreement to CE-MRI for the overall and regional impressions of synovitis, as well as good inter- and intra- rater agreement. Further, radiologists rated qDESSLow and qDESSHigh with moderate-to-high and moderate diagnostic confidence, respectively. This work shows the potential of the qDESS sequence as a non-contrast imaging technique for evaluation of synovitis.

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