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Abstract #4261

Reduced-FOV 3D MR-ARFI with a joint reconstruction for localizing the focused ultrasound beam in neuromodulation

Huiwen Luo1,2, Michelle K. Sigona1,2, Li Min Chen2,3, Charles F. Caskey2,3, and William A. Grissom1,2,3
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 3Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Magnetic resonance acoustic radiation force imaging (MR-ARFI) can be used to localize the focal spot in MR-guided focused ultrasound (FUS) by encoding the ultrasound-induced displacements into the phase of an MR image. A two-minute reduced-FOV 3D MR-ARFI scan with a joint image reconstruction method at 3 Tesla is proposed to image and localize the entire focus in FUS neuromodulation with a low FUS duty-cycle of 0.85%. In this work the reduced FOV MR-ARFI pulse sequence is demonstrated and the proposed k-space undersampling with joint sparse difference image reconstruction to achieve a two-minute scan time is validated.

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