Abstract #4261

Reduced-FOV 3D MR-ARFI with a joint reconstruction for localizing the focused ultrasound beam in neuromodulation

Huiwen Luo^1,2, Michelle K. Sigona^1,2, Li Min Chen^2,3, Charles F. Caskey^2,3, and William A. Grissom^1,2,3

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Magnetic resonance acoustic radiation force imaging (MR-ARFI) can be used to localize the focal spot in MR-guided focused ultrasound (FUS) by encoding the ultrasound-induced displacements into the phase of an MR image. A two-minute reduced-FOV 3D MR-ARFI scan with a joint image reconstruction method at 3 Tesla is proposed to image and localize the entire focus in FUS neuromodulation with a low FUS duty-cycle of 0.85%. In this work the reduced FOV MR-ARFI pulse sequence is demonstrated and the proposed k-space undersampling with joint sparse difference image reconstruction to achieve a two-minute scan time is validated.

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