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Abstract #4290

Probabilistic Tractography of the Arcuate Fasciculus: Sensitivity and Specificity of Standardised fMRI and Atlas-based Approaches

Jane Ansell1,2, Irène Brumer3, Jonathan Ashmore4, Enrico de Vita5, Josef Jarosz2, and Marco Borri2
1King's College London, London, United Kingdom, 2Department of Neuroradiology, King's College Hospital, London, United Kingdom, 3Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 4Department of Medical Physics and Bioengineering, NHS Highland, Inverness, United Kingdom, 5Department of Biomedical Engineering, School of Biomedical Engineering and Imagine Sciences, King's College London, London, United Kingdom

Atlas and fMRI-based approaches to standardise seed and end regions for probabilistic tractography of the arcuate fasciculus are investigated. fMRI-based approaches use spheres centered on language task peak activation. Within this pilot cohort, an atlas-based approach demonstrates the greatest sensitivity. fMRI-based approaches are more specific, but sensitivity can be increased by enlarging sphere size. Within each approach, a trade-off between sensitivity and specificity is seen as seed/end region size increases. For patients with abnormalities or lesions, where atlas approaches might be compromised, fMRI methods may be preferred. Further work to optimise fMRI-based approach is warranted, alongside application to patient data.

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