Abstract #4338

Cerebral circulation time related DMN connectivity in intracranial dural arteriovenous fistula before and after treatment

Bejoy Thomas¹, Jithin S S¹, Sabarish S Sekar¹, Santhosh Kannath¹, and Ramshekhar N Menon²

¹Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India, ²Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India

Cognitive decline is a common non-hemorrhagic complication of intracranial dural arteriovenous fistula (DAVF). Increase in cerebral circulation time (CCT) can be related to significant resting-state functional changes in the brain. 30 DAVF patients and a similar cohort of age-matched controls underwent resting-state functional MRI (rsfMRI) and the results were correlated with CCT and neuropsychological profile. Patients with high CCT showed decreased connectivity at DMN seed regions and less compensatory pre-frontal connectivity (pFDR < 0.05), which showed a trend in reversal after a month of embolisation therapy. These findings may be of significance in formulating treatment strategies in DAVF.

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