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Abstract #4348

Longitudinal analysis revealed increased parenchymal free water may be relieved by revascularization surgery in patients with moyamoya disease

Shoko Hara1,2, Masaaki Hori2,3, Yoji Tanaka1, Taketoshi Maehara1, Shigeki Aoki2, and Tadashi Nariai1
1Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, 2Radiology, Juntendo University, Tokyo, Japan, 3Radiology, Toho University Omori Medical Center, Tokyo, Japan

To investigate specific microstructural change after the revascularization surgery, we evaluated 13 patients with moyamoya disease and 13 age-sex matched normal controls using multishell diffusion MRI. By NODDI and free-water imaging analysis, preoperative hemispheres showed significant increase of extracellular fluid compared to controls, and subsequent significant decrease after the surgery. Only free-water eliminated parameter (orientation dispersion index) showed significant difference between patients with and without cognitive improvement after the surgery. Increased parenchymal free water observed in moyamoya disease may decrease after the surgery, and free-water elimination might be useful to detect true neuronal change related to postoperative cognitive improvement.

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