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Abstract #0031

In vivo measurement of bile metabolite concentrations at 3T by 1H STEAM MRS – breathing triggered navigation vs breath-hold acquisition.

Ivica Just1,2, Michael Leutner2, Stefan Wampl3, Radka Klepochová2, Siegfried Trattnig1,4,5, Alexandra Kautzky-Willer2, and Martin Krššák2
1High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 3High-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 4CD laboratory for Clinical Molecular MR imaging (MOLIMA), Vienna, Austria, 5Institute for Clinical Molecular MRI in the Musculoskeletal System, Karl Landsteiner Society, St. Pölten, Austria


Detection of metabolites from human gallbladder poses some challenges due to its size and position. We compared breath-hold and respiratory triggered acquisition by 1H SVS STEAM sequence on patients in supine position at 3T. 14 peaks of bile components were detected using both acquisition setups. Quantification of metabolite concentrations, corrected with measured T2app relaxation times, showed results within the range of previously published data. STEAM sequence proved to be feasible for measurement of bile components at 3T in vivo, providing sufficient spectral quality for metabolite quantification in supine position with comparable results in both breath-hold and PACE navigated acquisition.

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