Abstract #0039

Radio-pathomic associations between MRI and complex histomorphometric features of prostate cancer

Savannah R. Duenweg¹, Samuel A Bobholz², Allison K Lowman³, Michael Brehler³, Fitzgerald Kyereme³, Kenneth A Iczkowski⁴, and Peter S LaViolette^3,5

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ²Biophysics, Medical College of Wisconsin, Wauwatosa, WI, United States, ³Radiology, Medical College of Wisconsin, Wauwatosa, WI, United States, ⁴Pathology, Medical College of Wisconsin, Wauwatosa, WI, United States, ⁵Biomedical Engineering, Medical College of Wisconsin, Wauwatosa, WI, United States

Synopsis

This study used digitized histology and MP-MRI from 48 patients with prostate cancer (PCa) to determine the relationship between complex histomorphometric features of PCa histology and MRI features. After prostatectomy, tissue samples were digitized, and co-registered to the T2 image. Slides were annotated by a pathologist, individual glands were identified using automated image processing algorithms, and histomorphometric features were calculated. Radiomic features were calculated to compare higher order texture and histological features. We found that lumen was more strongly associated with raw intensity, whereas epithelial features were more strongly associated with computed texture features.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.