Radio-pathomic associations between MRI and complex histomorphometric features of prostate cancer
Savannah R. Duenweg1, Samuel A Bobholz2, Allison K Lowman3, Michael Brehler3, Fitzgerald Kyereme3, Kenneth A Iczkowski4, and Peter S LaViolette3,5
1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Biophysics, Medical College of Wisconsin, Wauwatosa, WI, United States, 3Radiology, Medical College of Wisconsin, Wauwatosa, WI, United States, 4Pathology, Medical College of Wisconsin, Wauwatosa, WI, United States, 5Biomedical Engineering, Medical College of Wisconsin, Wauwatosa, WI, United States
This study used digitized histology and MP-MRI from 48 patients with prostate cancer (PCa) to determine the relationship between complex histomorphometric features of PCa histology and MRI features. After prostatectomy, tissue samples were digitized, and co-registered to the T2 image. Slides were annotated by a pathologist, individual glands were identified using automated image processing algorithms, and histomorphometric features were calculated. Radiomic features were calculated to compare higher order texture and histological features. We found that lumen was more strongly associated with raw intensity, whereas epithelial features were more strongly associated with computed texture features.
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