Abstract #0085

4D flow MRI derived global intracranial pulse wave velocity and T1 white matter hypointensities among a population-based group of older people

Cecilia Björnfot¹, Anders Eklund^1,2, Jenny Larsson³, William Hansson³, Sara Qvarlander¹, Lars-Owe Koskinen³, Jan Malm³, and Anders Wåhlin^1,2,4

¹Department of Radiation Sciences, Umeå University, Umeå, Sweden, ²Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden, ³Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden, ⁴Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden

Synopsis

Arterial stiffening occurs with age and could be detrimental to the brain through several pathways. This potentially aggravates factors causing cerebral small vessel disease. We assessed arterial stiffness of the intracranial arteries through a newly developed global intracranial pulse wave velocity (PWV) measurement using 4D flow MRI data in a population-based cohort of older people and compared it to white matter hypointensity volume (WMH). Results revealed a weak but significant correlation between WMH and PWV, suggesting that such PWV measurement could be a useful tool to assess the brain’s vascular health.

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