Arterial stiffening occurs with age and could be detrimental to the brain through several pathways. This potentially aggravates factors causing cerebral small vessel disease. We assessed arterial stiffness of the intracranial arteries through a newly developed global intracranial pulse wave velocity (PWV) measurement using 4D flow MRI data in a population-based cohort of older people and compared it to white matter hypointensity volume (WMH). Results revealed a weak but significant correlation between WMH and PWV, suggesting that such PWV measurement could be a useful tool to assess the brain’s vascular health.
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