4D flow MRI derived global intracranial pulse wave velocity and T1 white matter hypointensities among a population-based group of older people
Cecilia Björnfot1, Anders Eklund1,2, Jenny Larsson3, William Hansson3, Sara Qvarlander1, Lars-Owe Koskinen3, Jan Malm3, and Anders Wåhlin1,2,4
1Department of Radiation Sciences, Umeå University, Umeå, Sweden, 2Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden, 3Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden, 4Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden
Arterial stiffening occurs with age and could be detrimental to the brain through several pathways. This potentially aggravates factors causing cerebral small vessel disease. We assessed arterial stiffness of the intracranial arteries through a newly developed global intracranial pulse wave velocity (PWV) measurement using 4D flow MRI data in a population-based cohort of older people and compared it to white matter hypointensity volume (WMH). Results revealed a weak but significant correlation between WMH and PWV, suggesting that such PWV measurement could be a useful tool to assess the brain’s vascular health.
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