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Abstract #0162

In vivo demonstration of generalized anisotropy profiles for resolving boundaries between subcortical gray and white matter

Robert Jones1, Chiara Maffei1, Qiyuan Tian1, Susie Huang1, Vaanathi Sundaresan1, and Anastasia Yendiki1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA, United States

Synopsis

We investigate the use of generalized anisotropy profiles (GAPs) for delineating boundaries between subcortical gray and white matter in vivo. Replicating results from a previous ex vivo study, we show that GAPs, which are computed from the diffusion propagator, provide more informative contrasts than T1- and T2-weighted images or conventional diffusion metrics. An undersampled Cartesian-grid sampling of q-space can be used to obtain these profiles with a reasonable scan time. Thus, GAPs show promise as a multi-channel contrast that could be used in the future to improve structural segmentation.

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