Abstract #0164
Evaluation of perfusion effects on HP[1-13C]pyruvate imaging parameters in patients with glioblastoma
Sana Vaziri1, Adam Autry1, Marisa Lafontaine1, Janine M Lupo1, Jeremy W Gordon1, Jasmine Hu1, Hsin-Yu Chen1, Yaewon Kim1, Javier Villanueva-Meyer1, Susan M Chang2, Jennifer Clarke2,3, Nancy Ann Oberheim Bush2,3, Duan Xu1, Peder EZ Larson1, Daniel B Vigneron1,4, and Yan Li1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States, 3Department of Neurology, University of California, San Francisco, San Francisco, CA, United States, 4Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, United States
Synopsis
Dynamic hyperpolarized (HP) 13C metabolic imaging allows for non-invasive measurements of real-time enzymatic conversion of injected [1-13C]pyruvate to [1-13C]lactate. The HP signal depends on several factors, including perfusion and monocarboxylate transporter activity. Previously, a global increase of pyruvate-to-lactate apparent conversion rates values was found in patients with glioma after receiving anti-angiogenic therapies. To better understand the effects of tissue vasculature on HP signals, we investigated the relationship between HP[1-13C]pyruvate metabolism and 1H perfusion parameters in normal-appearing white matter patients with glioma.
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