Low field NMR Relaxometry Studies of Tumours with applications in Intraoperative Tumour Margin Assessment in Breast-Conserving Surgery
Simona Baroni1, Valeria Bitonto1, Maria Rosaria Ruggiero1, Alessandra Pittaro2, isabella Castellano2, Riccardo Bussone3, Lionel M. Broche4, David J. Lurie4, Silvio Aime1,5, and Simonetta Geninatti Crich1
1Department of Molecular Biotechnology and Health Sciences - Molecular Imaging Center, University of Turin, Torino, Italy, 2Department of Medical Sciences, University of Turin, Torino, Italy, 3Breast Unit, Ospedale Cottolengo, Torino, Italy, 4University of Aberdeen, Aberdeen, United Kingdom, 5IRCCS SDN, Napoli, Italy
A new methodology, based on low field NMR relaxometry, has been employed to characterize breast tumour tissue and to tackle the important clinical need for the assessment of tumour margins during breast-conserving surgery. The method relies on the acquisition of proton longitudinal relaxation rate at low magnetic field strengths which are affected by the changes in the composition of the mammary gland tissue occurring during the development of neoplasia. A sensitivity, specificity, and accuracy of 92%, 85%, and 89%, respectively, were achieved. The information obtained has the potential to support the surgeon in real-time margin assessment.
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