Abstract #0197

Diffusely abnormal white matter microstructural changes are similar across the clinical phenotypes of multiple sclerosis

Irene Margaret Vavasour^1,2, Pierre Becquart¹, Tigris Joseph^1,2, Jasmine Gill¹, Guojun Zhao³, Farhia Abdullahi¹, Emily Kamma¹, Kaya Frese¹, Robert Carruthers¹, Shannon H Kolind^1,2,3, Alice Schabas¹, Ana-Luiza Sayao¹, Virginia Devonshire¹, Roger Tam^1,3, GR Wayne Moore^1,2, Sophie Stukas¹, Cheryl Wellington¹, Jacqueline Quandt¹, Anthony Traboulsee^1,3, David Li^1,3, and Cornelia Laule^1,2

¹University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ³MSMRI Research Group, Vancouver, BC, Canada

Synopsis

Diffusely abnormal white matter (DAWM) is commonly found on conventional brain MRI in all stages of multiple sclerosis (MS). Blood markers associated with prior or ongoing myelin and axonal damage were not found to be elevated in people with DAWM relative to people without DAWM. Within areas of DAWM, no differences between MS phenotypes were found possibly suggesting that the tissue abnormalities within DAWM are similar across the clinical course, from early to late stages of MS.

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