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Abstract #0197

Diffusely abnormal white matter microstructural changes are similar across the clinical phenotypes of multiple sclerosis

Irene Margaret Vavasour1,2, Pierre Becquart1, Tigris Joseph1,2, Jasmine Gill1, Guojun Zhao3, Farhia Abdullahi1, Emily Kamma1, Kaya Frese1, Robert Carruthers1, Shannon H Kolind1,2,3, Alice Schabas1, Ana-Luiza Sayao1, Virginia Devonshire1, Roger Tam1,3, GR Wayne Moore1,2, Sophie Stukas1, Cheryl Wellington1, Jacqueline Quandt1, Anthony Traboulsee1,3, David Li1,3, and Cornelia Laule1,2
1University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 3MSMRI Research Group, Vancouver, BC, Canada


Diffusely abnormal white matter (DAWM) is commonly found on conventional brain MRI in all stages of multiple sclerosis (MS). Blood markers associated with prior or ongoing myelin and axonal damage were not found to be elevated in people with DAWM relative to people without DAWM. Within areas of DAWM, no differences between MS phenotypes were found possibly suggesting that the tissue abnormalities within DAWM are similar across the clinical course, from early to late stages of MS.

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