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Abstract #0246

Integration of blip reversal with CAIPI sampling enables simultaneous correction of slice aliasing and distortion in 3D multi-slab diffusion MRI

Ziyu Li1, Karla L. Miller1, and Wenchuan Wu1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom


3D EPI can provide optimal SNR efficiency for high-resolution diffusion MRI but is prone to aliasing of edge slices and in-plane distortion artifacts. We propose a highly-efficient method for correcting slice-aliasing and distortion for 3D multi-slab imaging without increasing scan time. Blip reversal is integrated into CAIPI sampling within a single scan. In addition, we extend the FOV along the slice direction to remove slice-aliasing artifacts. Field maps are estimated from the blip-reversed data and incorporated in the final joint reconstruction. The efficacy of the method is quantitatively and systematically validated using highly realistic simulations.

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