3D EPI can provide optimal SNR efficiency for high-resolution diffusion MRI but is prone to aliasing of edge slices and in-plane distortion artifacts. We propose a highly-efficient method for correcting slice-aliasing and distortion for 3D multi-slab imaging without increasing scan time. Blip reversal is integrated into CAIPI sampling within a single scan. In addition, we extend the FOV along the slice direction to remove slice-aliasing artifacts. Field maps are estimated from the blip-reversed data and incorporated in the final joint reconstruction. The efficacy of the method is quantitatively and systematically validated using highly realistic simulations.
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