Abstract #0248

Integrating time division multiplexing (TDM) and simultaneous multi-slice (SMS) for accelerating combined diffusion-relaxometry

Yang Ji^1,2, William Scott Hoge³, Borjan Gagoski⁴, Carl-Fredrik Westin ³, Yogesh Rathi^1,3, and Lipeng Ning¹

¹Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ²Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ³Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ⁴Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States

Synopsis

We introduce an MRI sequence that integrates the time-division multiplexing (TDM) technique and simultaneous multi-slice (SMS) method to achieve a high slice-acceleration (~6x) factor for acquiring relaxation-diffusion MRI. Two variants of the sequence, i.e., TDM3e-SMS and TDM2s-SMS, were developed to simultaneously acquire slice groups with 3 distinct echo times (TEs) and 2 slice groups with the same TE, respectively. Both sequences were evaluated on a 3T scanner with in-vivo human brains and compared with standard single-band (SB) EPI and SMS-EPI using diffusion measures and tractography results. Results have shown that TDM-SMS provides reliable measures for relaxation-diffusion and standard diffusion MRI.

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