Abstract #0251

Mapping water exchange in the human brain using diffusion MRI with free waveform encoding

Arthur Chakwizira¹, Filip Szczepankiewicz², Carl-Fredrik Westin³, Geraline Vis⁴, Linda Knutsson^1,5,6, Pia Sundgren^7,8,9,10, and Markus Nilsson²

¹Medical Radiation Physics, Lund, Lund University, Lund, Sweden, ²Clinical Sciences Lund, Lund University, Lund, Sweden, ³Department of Radiology, Brigham and Women's hospital, Harvard Medical School, Boston, MA, United States, ⁴Department of Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden, ⁵Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁷Department of Diagnostic Radiology, Lund University, Lund, Sweden, ⁸Lund University Bioimaging Center, Lund University, Lund, Sweden, ⁹Department for Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden, ¹⁰Department of Radiology, University of Michigan, Ann Arbor, MI, United States

Synopsis

Temporal velocity correlations of diffusing particles carry information about the structure of the diffusion environment. Studying high-order velocity autocorrelation functions can aid in understanding how signal is influenced by restricted diffusion and exchange, and in turn how to design experiments that are sensitive/independent to these phenomena. In this work, we employ numerical simulations on a variety of substrates to demonstrate this notion. We find that the fourth order velocity autocorrelation bears a distinctive signature of exchanging systems. In addition, we highlight that the effect of exchange on the second order velocity autocorrelation is negligible when exchange is barrier-limited.

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